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Yes, it is possible to play electric guitar in bed, but it may be uncomfortable for extended periods of time. You would need to have a power outlet nearby to plug in the guitar amplifier and enough space to comfortably hold and move the guitar. The bed may also absorb some of the amplified sound, so a nearby wall or other surface to direct the sound towards could improve the experience. Additionally, be aware of the time and volume to avoid disturbing others, especially during late-night sessions.